Helen Mirren portrays Patricia Highsmith in the upcoming film A Talent for Murder, under the direction of Anton Corbijn. Critics have characterized her performance as biting and abrasive. Mirren has said Highsmith the most difficult real person she has ever played, emphasizing her difficult personality.

Mirren and Brosnan stood up for the actor Tom Hardy following gossip about issues during the filming of MobLand. She spoke about the role at the Toronto film festival.